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UQCRC1 and UQCRC2 are homologs to the mitochondrial-processing peptidase subunits and are predicted to process UQCRFS1 in situ during cIII assembly (Fernandez-Vizarra and Zeviani, 2018)

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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. In semaglutides extension, about two-thirds returned within one year. The pattern reflects removal of appetite suppression after major weight loss

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